The SSADH(succinic semialdehyde dehydrogenase) is a portein linked to epilepsy and other brain function abnormalities.
Understanding its structure provides an important clue in revealing the mechanism of how they develop, and could present new opportunities in treatment and drug development.
The deficiency of SSADH, which results in an up-regulation of GABA(gamma-aminobutyric acid) levels in the brain, has been pointed to as the cause for nerve cells in the brain becoming overly active, but there has been little research on what causes SSADH functions to deteriorate.
And a team of Korean researchers of Pohang University of science and Technology (POSTECH) found that SSADH loses its ability to interact with SSA(succinic semialdehyde) when it becomes oxidized by reactive oxygen.
Their findigs were presented in a study published by peer-review European Molecular Biology Organization (EMBO) Journal. <헬스코리아뉴스>
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