According to their study, TORC2 protein, a key regulator of blood glucose levels, is also involved in increasing the liver's output of LIPIN1 proteins, which are associated with insulin resistance.
Insulin resistance prevents the body from processing insulin properly, thus increasing the risks of conditions such as diabetes, as body cells are prevented from processing glucose.
The level of LIPIN1 in the livers of obese mice was up-regulated after the increase of TORC2 activation. This leads to elevation of diacylglycerol in the liver, which then causes the over-expression of protein kinase C (PKC) epsilon that is involved with insulin resistance.
But, in mice with developed insulin resistance, a regulation of LIPIN1 resulted in the weakening of insulin resistance, which then led to a lowered output of glucose in the liver.
According to the researcher, the regulation of TORC2 could improve the conditions of insulin resistance, which also opens new opportunities for a more targeted approach in treatments.
The finding were published in the peer-review journal, Cell Metabolism. <헬스코리아뉴스>
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